References of Oral Food Challenges or Double-Blind Placebo-Controlled Food Challenges (DBPCFCs),

Oral food challenges are procedures conducted to make an accurate diagnosis of immediate, and occasionally delayed, adverse reactions to foods. The timing of the challenge is carefully chosen based on the individual patient history and the results of skin prick tests and food specific serum IgE values. The type of the challenge is determined by the history, the age of the patient, and the likelihood of encountering subjective reactions. The food challenge requires preparation of the patient for the procedure and preparation of the office for the organized conduct of the challenge, for a careful assessment of the symptoms and signs and the treatment of reactions. The starting dose, the escalation of the dosing, and the intervals between doses are determined based on experience and the patient’s history. The interpretation of the results of the challenge and arragements for follow-up after a challenge are important. A negative oral food challenge result allows introduction of the food into the diet, whereas a positive oral food challenge result provides a sound basis for continued avoidance of the food.

Diagnostic oral food challenges (OFCs), introduced in clinical practice by May 1976 in the form of double-blind, placebo-controlled food challenges (DBPCFCs), are procedures that may be used to establish definitively whether a food is the cause of adverse reactions. They are used as clinically indicated, either at initial diagnosis or during follow-up. This article is intended to provide a practical and comprehensive guide to aid allergists/immunologists, who are uniquely qualified to perform diagnostic OFCs, in the use of the procedure for patient care in a scientifically sound, safe, and practical manner. It describes approaches used by allergists/immunologists in the United States and incorporates critically reviewed published international experience. Additional resources are “Food Allergy: A Practice Parameter” and “A Health Professional’s Guide to Office Food Challenges.”

Decision process regarding selection of open vs blind OFCs. Blinded portions of the OFC must always be followed by an open feeding with an age-appropriate serving of food in its natural form or the least cooked/baked/processed form of food that will be incorporated into the patient’s diet at home. source: American Academy of Allergy, Asthma & Immunology

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Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.

Copyright © 2012, Children Allergy Clinic Online Information Education Network. All rights reserved

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