Children with Short Stature Born Small and GH Trial

Food Intake of Children with Short Stature Born Small for Gestational Age before and during a Randomized GH Trial

V.H. Boonstraa, N.J.T. Arendsa, T. Stijnenb, W.F. Blumc, O. Akkermana, A.C.S. Hokken-Koelegaa

Abstract

Parents of short children born SGA often report that their children have a serious lack of appetite and a low food intake. In this study we investigated food intake, by using a standardized 7-day food questionnaire, in 88 short SGA children before start of GH treatment. The intake was compared with the recommended daily intake (RDI) of age-matched children. We also compared the food intake of GH-treated children (n = 62) with randomized controls (n = 26) after 1 year of GH treatment. In addition, we evaluated the effect of food intake and GH treatment on body composition and serum levels of IGF-I, IGFBP-3 and leptin. Our study shows that caloric intake, fat and carbohydrate intake of short SGA children aged 5.9 (1.6) years was significantly lower compared to the RDI for age-matched children. One year of GH treatment resulted in a significant increase of caloric, fat, carbohydrate and protein intake compared to baseline. Compared to randomized controls, caloric, carbohydrate and protein intake increased significantly after 1 year of GH treatment. Short SGA children had significantly lower SDS scores for LBM, fat mass, skinfold (SF) and BMI compared to age-matched references. They also had significantly lower serum IGF-I, IGFBP-3 and leptin levels. GH treatment resulted in a significant increase of height, LBM, BMI, IGF-I and IGFBP-3 SDS and a significant decrease of SF SDS and leptin SDS. In conclusion, our study shows that short SGA children have indeed a lower food intake than age-matched controls. During GH treatment the food intake increased significantly compared to baseline in contrast to the randomized control group.

source: Division of Endocrinology, Department of Pediatrics, Sophia Children’s Hospital/Erasmus University, and bInstitute of Epidemiology and Biostatistics, Erasmus University, Rotterdam, The Netherlands; Lilly Research Laboratories, University Children’s Hospital, Giessen, Germany

supported by

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