Serotonin neurotransmission in anorexia nervosa.
Behav Pharmacol. 2012 Sep;23(5-6):478-95.
Source: Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research, University of Karachi, Karachi, Pakistan.
Patients with anorexia nervosa (AN) show extreme dieting weight loss, hyperactivity, depression/anxiety, self-control, and behavioral impulsivity. 5-Hydroxytryptamine (5-HT; serotonin) is involved in almost all the behavioral changes observed in AN patients. Both genetic and environmental factors contribute toward the pathogenesis of AN. It is a frequent disorder among adolescent girls and young women and starts as an attempt to lose weight to look beautiful and attractive. Failure to see the turning point when fasting becomes unreasonable leads to malnutrition and AN. Tryptophan, the precursor of serotonin and an essential amino acid, is only available in the diet. It is therefore likely that excessive diet restriction and malnutrition decrease brain serotonin stores because the precursor is less available to the rate-limiting enzyme of 5-HT biosynthesis, which normally exists unsaturated with its substrate. Evidence shows that diet restriction-induced exaggerated feedback control over 5-HT synthesis and the smaller availability of tryptophan decreases serotonin neurotransmission at postsynaptic sites, leading to hyperactivity, depression, and behavioral impulsivity. A compensatory upregulation of postsynaptic 5-HT-1A receptors and hypophagic serotonin receptors may be involved in anxiety and suppression of appetite. It is suggested that tryptophan supplementation may improve pharmacotherapy in AN.
PICKY EATERS CLINIC Klinik Khusus Kesulitan Makan Pada Anak dan GROW UP CLINIC Klinik Khusus Gangguan Pertumbuhan Berat Badan Anak Yudhasmara Foundation www.pickyeaterschild.wordpress.com/ email : email@example.com
WORKING TOGETHER FOR STRONGER, HEALTHIER AND SMARTER CHILDREN BY EDUCATION, CLINICAL INTERVENTION, RESEARCH AND NETWORKING INFORMATION. Advancing of the future pediatric and future parenting to optimalized physical, mental and social health and well being for fetal, newborn, infant, children, adolescents and young adult
CHILDREN GROW UP CLINIC I
- CHILDREN GROW UP CLINIC I, JL Taman Bendungan Asahan 5 Bendungan Hilir Jakarta Pusat 10210 Phone : 5703646 – 44466102
- CHILDREN GROW UP CLINIC II, MENTENG SQUARE Jl Matraman 30 Jakarta Pusat 10430 Phone 44466103 – 97730777
|LAYANAN KLINIK KHUSUS “CHILDREN GRoW UP CLINIC”
PROFESIONAL MEDIS “CHILDREN GRoW UP CLINIC”
Clinical – Editor in Chief :
Dr WIDODO JUDARWANTO, pediatrician
- email : firstname.lastname@example.org
- curriculum vitae
- For Daily Newsletter join with this Twitter https://twitter.com/WidoJudarwanto
Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider
Copyright © 2012, Picky Eaters and Grow Up Clinic, Information Education Network. All rights reserved